Burden, Predictors And Case Fatality of Neonatal Asphyxia Amongst Neonates At The Limbe Regional Hospital, A Low-Income Setting

Authors

  • Naiza Monono Author
  • Joshua Tambe Author
  • Kamo Doka Author
  • Isabelle Mekone Author
  • Vanessa Denghir Author
  • Evelyne Mah Author

Keywords:

Neonatal Asphyxia, Associated factors, Outcome, Case fatality

Abstract

Background: Neonatal asphyxia is a global problem which significantly contributes to both neonatal morbidity and mortality. According to the World Health Organisation,4 million neonates are affected by asphyxia annually. In Cameroon, particularly in the South-West region, useful information concerning this neonatal dilemma is limited. So, we decided to determine the prevalence of neonatal asphyxia, to identify the associated factors and hospital outcome of affected neonates at the Limbe Regional Hospital.

Methods: A 3-year retrospective analytic study from January 2017-December 2019 was carried out from February 2020 to April 2020 including files of term babies unable to breathe by its own effort with Apgar score of less than 7 at 5th mn.

Results: A total of 175 (27.7%) neonates were asphyxiated. We found that the following were independently associated with neonatal asphyxia, antepartum: < 3 obstetric ultrasounds (AOR = 1.92 [1.09-3.38]), negative HIV status (AOR:0.2 [0.09-0.55]), intrapartum: augmented labour (AOR:2.88 [1.03-8.03]) and meconium-stained liquor (AOR: 4.13 [1.7-10.05]). Hospital mortality rate was 4.4% with a case fatality rate of 16% and a threefold chance of dying if the case of asphyxia was referred from another health institution.

Conclusion: The factors associated with neonatal asphyxia are preventable. Thus, efforts should be made to improve the quality of antenatal and intrapartum care services to reduce the burden of neonatal asphyxia. 

Keywords: Neonatal Asphyxia, Associated factors, Outcome, Case fatality

References

Bryce J, Boschi-Pinto C, Shibuya K, Black RE, WHO Child Health Epidemiology Reference Group. WHO estimates of the causes of death in children. Lancet London England. 2005 ;365(9465):1147–52.

Kriebs JM. Guidelines for Perinatal Care, Sixth Edition : By the American Academy of Pediatrics and the American College of Obstetricians and Gynecologists. Journal of Midwifery and Women's Health. 2010 ;55(2):e37–e37.

Ernest M, Graham, Kristy A, Adam L, Hartman, Frances J et al. A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. American Journal of Obstetrics & Gynecology. 2008;199(6):587- 595.

Azra Haider B, Bhutta ZA. Birth Asphyxia in Developing Countries: Current Status and Public Health Implications. Current Problems and Pediatric Adolescent Health Care. 2006 ;36(5):178–88.

Monebenimp F, Tietche F, Eteki N. Asphyxie neonatale au centre hospitalier et Universitaire de Yaounde, Cameroun. Clinics in Mother and Child Health. 2005;2(2).

Chiabi A, Nguefack S, Mah E, Nodem S, Mbuagbaw L. Risk Factors for Birth Asphyxia in an Urban Health Facility in Cameroon. Iran Journal of Child Neurology. 2013;7(3):46–54.

Tchouankeu FK. Asphyxie néonatale au Centre Mère et Enfant de la Fondation Chantal Biya: aspects épidémiologiques, cliniques et évolutifs. The Journal of Medicine and Health Sciences; 2015. Available from: https://www.hsdfmsb.org/index.php/hsd/thesis/view/331 [accessed 2020 Jul 4].

Douanla Nodem, T,Tchokoteu, Chiabi M, Mah E. Facteurs de risques et évolution intrahospitalière de l’asphyxie néonatale à l’hôpital gynécologique, obstétrique et pédiatrique de Yaoundé au Cameroun. Available from: https://www.memoireonline.com/ [accessed 2020 Jul 4]

Abdo RA, Halil HM, Kebede BA, Anshebo AA, Gejo NG. Prevalence and contributing factors of birth asphyxia among the neonates delivered at Nigist Eleni Mohammed memorial teaching hospital, Southern Ethiopia: a cross-sectional study. BioMed Central Pregnancy Childbirth. 2019;19(1):536.

Wosenu L, Worku AG, Teshome DF, Gelagay AA. Determinants of birth asphyxia among live birth newborns in University of Gondar referral hospital, northwest Ethiopia: A case-control study. PloS one. 2018 Sep 7;13(9):e0203763.

Wood S, Crawford S, Hicks M, Mohammad K. Hospital-related, maternal, and fetal risk factors for neonatal asphyxia and moderate or severe hypoxic-ischemic encephalopathy: a retrospective cohort study. Journal of Maternal, Fetal and Neonatal Medicine. 2019 ;1–6.

Robertson CM, Perlman M. Follow-up of the term infant after hypoxic-ischemic encephalopathy. Paediatric Child Health Journal. 2006 ;11(5):278–82.

Vannucci RC, Perlman JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics. 2011;100(6):1004–1114.

Gebreheat G, Tsegay T, Kiros D, Teame H, Etsay N, et al. Prevalence and Associated Factors of Perinatal Asphyxia among Neonates in General Hospitals of Tigray, Ethiopia, 2018. BioMed Research International. ;2018. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236773/ [accessed 2019 Nov 24 ]

Alemu A, Melaku G, Abera GB, Damte A. Prevalence and associated factors of perinatal asphyxia among newborns in Dilla University referral hospital, Southern Ethiopia– 2017. Pediatric Health, Medicine and Therapeutics. 2019;10:69– 74.[accessed

The World Bank. Mortality rate, neonatal (per 1,000 live births). Available from: https://data.worldbank.org/indicator/ [accessed 2020 Jul 21]

United Nations Sustainable Development. Summit Charts New Era of Sustainable Development. Available from: https://www.un.org/sustainabledevelopment/blog/2015/09/summit-charts-neweraof-sustainable-development-world-leaders-to-gavel-universal-agenda-to-transformour-world-for-people-and-planet/[ 2020 Jul 25].

Garba B, Sakajiki M, Musa A, Kolawole T, Adeniji A, et al. Prevalence and Risk Factors for Perinatal Asphyxia as Seen at a Specialist Hospital in Gusau, Nigeria. Subsaharan African Journal of Medicine. 2018;2(2).

WHO.Standard treatment Protocols for management of sick newborns in small hospitals. Available from: https://www.newbornwhocc.org/spt.html [accessed 2019 Nov 22].

Manandhar SR, Basnet R. Prevalence of Perinatal Asphyxia in Neonates at a Tertiary Care Hospital: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2019 Sep-Oct;57(219):287-292.

Woday A, Muluneh A, Denis CS. Birth asphyxia and its associated factors among newborns in public hospital, northeast Amhara, Ethiopia. PLOS ONE. 2019 déc;14(12):0226891.

Solayman M, Hoque S, Happy T, Islam M, Islam M. Prevalence of Perinatal Asphyxia with Evaluation of Associated Risk Factors in a Rural Tertiary Level Hospital. Khwaja Yunus Ali Medical College Journal. 2017;8:43.

Laopaiboon M, Lumbiganon P, Intarut N, Mori R, Ganchimeg T, Vogel JP et al. WHO Multicountry Survey on Maternal Newborn Health Research Network. Advanced maternal age and pregnancy outcomes: a multicountry assessment. BJOG International Journal of Obstetrics and Gynaecology. 2014;121 Suppl 1:49–56.

Foumane P, Nkomom G, Mboudou E, Julius Sama D, Nguefack S, Moifo B. Risk factors of clinical birth asphyxia and subsequent newborn death following nuchal cord in a low-resource setting. Journal of Obstetrics and Gynecology. 2013; 03:642–7.

Wiafe Y, Odoi A, Dassah E. The role of obstetric ultrasound in reducing maternal and perinatal mortality. Ultrasound imaging–medical applications. Rijeka, Croatia: InTech. 2011 Aug 23;23:207-34.

Yadav N, Damke S. Study of risk factors in children with birth asphyxia. International Journal of Contemporary Pediatric. 2017; 4:518.

Tournemire A.Evaluation de la qualite de la prise en charge d' expulsion: Etude cas temoins a propos de 81 cas d'asphyxie per-partum compares a 81 enfants sains.Universite de Toulouse III Sabatier. 2014:158.

Sendeku FW, Azeze GG, Fenta SL. Perinatal asphyxia and its associated factors in Ethiopia: a systematic review and meta-analysis. BMC pediatrics. 2020 Dec;20:1-1.

Ugwu GM, Abedi HO, Ugwu EN. Incidence of birth asphyxia as seen in central hospital and GN children’s clinic both in Warri Niger Delta of Nigeria: an eight year retrospective review. Global journal of health science. 2012 Sep;4(5):140.

Dalal EA, Bodar NL. A Study on Birth Asphyxia at Tertiary Health Centre. India. National Journal of Medical Research. 2013; 3(4):3.

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Published

2024-05-27

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How to Cite

[1]
Monono, N. et al. 2024. Burden, Predictors And Case Fatality of Neonatal Asphyxia Amongst Neonates At The Limbe Regional Hospital, A Low-Income Setting. The African Journal of Perinatology. 1, 1 (May 2024), 4–14.

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